I prepared a little collage showcasing our recent bioimaging highlights…
Tissue Biology Showcase Video
As the lab is now officially associated with the OICE as part of the Exploratory Research Unit (ERU), I created short video showcasing the different bioimaging approaches and areas of interest… check it out below
Verstopfung in Abwehrzellen löst Entzündung aus
FAU issued a press release on our recent Science paper. Check it out here [German].
Effectors versus Protectors: How Anti-inflammatory Tissue Macrophages Maintain Tissue Homeostasis
On January 24th, 2018, I had the honor of giving a lecture for the Immunonology IG seminar series at NIAID/NIH on “Effectors versus Protectors: How Anti-inflammatory Tissue Macrophages Maintain Tissue Homeostasis“. The talk was recorded and is permanently archived here.
King et al., Science 2020
Water loss regulates cell and vesicle volume
Jason S. King and Elizabeth Smythe wrote a preview to our recent paper in Science.
Check out the paper here [$] or contact to request a copy.
SUMMARY When cells take up extracellular fluid by endocytosis, they internalize a considerable proportion of the cell volume quickly and yet maintain their volume and ionic composition. This is particularly striking in the case of macropinocytosis, which is the bulk uptake of extracellular fluid. Through this pathway, macrophages can be stimulated to internalize ∼25% of their cellular volume per hour into large vacuoles known as macropinosomes. An intriguing question is how cells and organelles are able to maintain their size while internalizing such large volumes. On page 301 of this issue, Freeman et al. reveal a molecular mechanism underpinning homeostatic regulation of cell size. They demonstrate that newly formed macropinosomes rapidly lose volume by osmosis driven by two-pore channel (TPC)–mediated outflow of sodium ions. This reduces hydrostatic pressure within the macropinosome, facilitating the extension of tubules from the macropinosome surface and recycling of membrane lipids and proteins back to the cell surface.