the work

Popular science

Feature in P.M. (04/2020)


In April’s issue of Germany’s popular science magazine P.M., the lab got featured in a small section introducing young scientists and their research [German].

Screenshot of P.M. issue 04/2020
ampuls 1-2020

Verstopfte Immunzellen lösen Entzündung aus


UK Erlangen’s employee magazine ampuls featured a short paragraph on our latest paper in Science. See screenshot below [German]

Youtube video

Tissue Biology Showcase Video


As the lab is now officially associated with the OICE as part of the Exploratory Research Unit (ERU), I created short video showcasing the different bioimaging approaches and areas of interest… check it out below

Videocast

Effectors versus Protectors:
How Anti-inflammatory Tissue Macrophages Maintain Tissue Homeostasis

On January 24th, 2018, I had the honor of giving a lecture for the Immunonology IG seminar series at NIAID/NIH on “Effectors versus Protectors: How Anti-inflammatory Tissue Macrophages Maintain Tissue Homeostasis“. The talk was recorded and is permanently archived here.

King et al., Science 2020

Water loss regulates cell and vesicle volume


Jason S. King and Elizabeth Smythe wrote a preview to our recent paper in Science.

Check out the paper here [$] or contact to request a copy.

SUMMARY When cells take up extracellular fluid by endocytosis, they internalize a considerable proportion of the cell volume quickly and yet maintain their volume and ionic composition. This is particularly striking in the case of macropinocytosis, which is the bulk uptake of extracellular fluid. Through this pathway, macrophages can be stimulated to internalize ∼25% of their cellular volume per hour into large vacuoles known as macropinosomes. An intriguing question is how cells and organelles are able to maintain their size while internalizing such large volumes. On page 301 of this issue, Freeman et al. reveal a molecular mechanism underpinning homeostatic regulation of cell size. They demonstrate that newly formed macropinosomes rapidly lose volume by osmosis driven by two-pore channel (TPC)–mediated outflow of sodium ions. This reduces hydrostatic pressure within the macropinosome, facilitating the extension of tubules from the macropinosome surface and recycling of membrane lipids and proteins back to the cell surface.