Exploring Molecular Mechanisms of Tissue Protection
Digital Illustration from Atoms to Cells
HIGHLIGHTS > Check out the art and science of David Goodsell > You can now create your own: CellPAINT > Here, I used a bunch of Goodsell’s beautiful molecules and structures, and made my own collage in Photoshop showing a phagocyte taking up debris.
Professor for Rheumatology
HIGHLIGHTS > Last Friday, I was appointed a Professor at FAU. Good times ahead!
Using Blender 2.8 to visualize microglia morphology
EXPLORING THE SPACE! Blender is an open-source 3D content creation suite, and it is free of charge! At first, the GUI and general handling can be a bit intimidating, and the learning curve is quite steep, but the performance is simply impressive. Using a Cx3cr1-gfp reporter system, I visualized microglia within 200 μm brain slices trying to capture their entire dendrite morphology. Iso-surfaces were created in IMARIS, exported as .wrl, imported into blender, custom-texturized, and rendered. Hover over images to zoom.
Explore macrophage biology 3D
Interactive 3D model of a cloaking, resident tissue macrophage
SKETCHFAB We are always looking for ways to better visualize and communicate the lab’s science. This is pretty cool: Sketchfab allows you to upload 3D models people can directly interact with, supposed to also have VR options… and you directly embed the model into your website. So click it, drag it, spin it, zoom in and out, and go wild with it…
DESCRIPTIONIntravital microscopy allowed me to capture this individual resident tissue macrophage in the process of sending long membranous processes towards a laser-induced sterile stromal damage in order to contain it (“cloaking”). Fluorescence intensity data was rendered as an iso-surface in IMARIS, exported as .vrml, processed in MeshLab, saved as .stl, uploaded to Sketchfab, and finally ended up here. A long way for a single cell. Enjoy!