Our lab is seeking to understand the immune system on a cellular and subcellular level, making it tangible through cutting edge technology and intravital imaging and compelling visuals, in order to develop therapies for the treatment and prevention of inflammatory diseases.
Interested or curious? The lab is currently in “setup mode” and applications for doctoral or postdoctoral positions are always welcome. Get in touch… Otherwise, positions will be announced here and communicated via social media, as soon as they become available.
Visualizing Cellular Dynamics in Damage Response…
Click here to explore recent key publications and get more informations. Or browse through more papers here [hover to stop; click to get link]:
Gottschalk et al., Cell Systems 2016
Uderhardt et al., Cell 2019
Freeman et al., Science 2020
Gottschalk et al., Elife 2019
Uderhardt et al., J Exp Med 2017
Uderhardt et al., Immunity 2012
In depth analysis of phagocyte functions…
The main objective of the lab is to employ integrative tissue-level bio-imaging to elucidate the cellular and molecular mechanisms tissues employ to protect themselves against unwanted immune responses. Specifically, we focus on the biology and the homeostatic functions of interstitial macrophages in vivo and explore how these cells operate during the onset of inflammation. Ultimate goal of our research is to therapeutically exploit the tissue-protective properties of these cells in order not only to treat but also prevent inflammatory diseases. As part of the OICE-Explorative Research Unit, we will establish and further advance intravital as well as in situ functional imaging approaches as tools for the exploration of spatiotemporal dynamics of immune effector cells within the context of biological tissues.